Ontology highlight
ABSTRACT:
SUBMITTER: Grubbs JJ
PROVIDER: S-EPMC7173979 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Grubbs Jeremy J JJ Lopes Lindsey E LE van der Linden Alexander M AM Raizen David M DM
PLoS biology 20200421 4
Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep pressure, have low ATP levels despite high-fat stores, indicating a defective response to cel ...[more]