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A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET.

ABSTRACT: BACKGROUND:Short periods of fasting and/or low-carbohydrate diet have been proven beneficial for decreasing the myocardial uptake of 18F-fluorodeoxyglucose (18F-FDG) and enhancing the detection of inflammatory heart diseases by 18F-FDG positron emission tomography (PET). This study aimed at determining whether this benefit is increased when a low-carbohydrate ketogenic diet is prolonged up to 7 days. METHODS:Wistar rats underwent serial 18F-FDG-PET imaging after an 18-hour fasting period and after 2, 4 and 7 days of a ketogenic diet (3% carbohydrate) and they were compared to rats submitted to the same protocol but with normal diet (44% carbohydrate). The 18F-FDG-PET/ketogenic protocol was also applied in rats with immune myocarditis (injection of porcine cardiac myosin). RESULTS:The 7-day ketogenic diet was associated with (1) a sustained increase in circulating ketone bodies at an equivalent level to that reached after 18-hour fasting, (2) a gradual decrease in 18F-FDG uptake within normal myocardium reaching a lower level compared to fasting at the 7th day (myocardium-to-blood ratios: 1.68?±?1.02 vs 3.25?±?1.40, P?

SUBMITTER: Clement A

PROVIDER: S-EPMC7174271 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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A 1-week extension of a ketogenic diet provides a further decrease in myocardial <sup>18</sup>F-FDG uptake and a high detectability of myocarditis with FDG-PET.

Clément Alexandra A Boutley Henri H Poussier Sylvain S Pierson Julien J Lhuillier Mickael M Kolodziej Allan A Olivier Jean-Luc JL Karcher Gilles G Marie Pierre-Yves PY Maskali Fatiha F

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20180820 2

<h4>Background</h4>Short periods of fasting and/or low-carbohydrate diet have been proven beneficial for decreasing the myocardial uptake of <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) and enhancing the detection of inflammatory heart diseases by <sup>18</sup>F-FDG positron emission tomography (PET). This study aimed at determining whether this benefit is increased when a low-carbohydrate ketogenic diet is prolonged up to 7 days.<h4>Methods</h4>Wistar rats underwent serial <sup>18</su ...[more]

PMID: 30128917

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Project description:IntroductionMetabolic brain network analysis based on graph theory using FDG PET imaging is potentially useful for investigating brain activity alternation due to metabolism changes in different stages of Alzheimer's disease (AD). Most studies on metabolic network construction have been based on group data. Here a novel approach in building an individual metabolic network was proposed to investigate individual metabolic network abnormalities.MethodFirst, a weighting matrix was calculated based on the interregional effect size difference of mean uptake between a single subject and average normal controls (NCs). Then the weighting matrix for a single subject was multiplied by a group-based connectivity matrix from an NC cohort. To study the performance of the proposed individual metabolic network, inter- and intra-hemispheric connectivity patterns in the groups of NC, sMCI (stable mild cognitive impairment), pMCI (progressive mild cognitive impairment), and AD using the proposed individual metabolic network were constructed and compared with those from the group-based results. The network parameters of global efficiency and clustering coefficient and the network density score (NDS) in the default-mode network (DMN) of generated individual metabolic networks were estimated and compared among the disease groups in AD.ResultsOur results show that the intra- and inter-hemispheric connectivity patterns estimated from our individual metabolic network are similar to those from the group-based method. In particular, the key patterns of occipital-parietal and occipital-temporal inter-regional connectivity deficits detected in the groupwise network study for differentiating different disease groups in AD were also found in the individual network. A reduction trend was observed for network parameters of global efficiency and clustering coefficient, and also for the NDS from NC, sMCI, pMCI, and AD. There was no significant difference between NC and sMCI for all network parameters.ConclusionWe proposed a novel method in constructing the individual metabolic network using a single-subject FDG PET image and a group-based NC connectivity matrix. The result has shown the effectiveness and feasibility of the proposed individual metabolic network in differentiating disease groups in AD. Future studies should include investigation of inter-individual variability and the correlation of individual network features to disease severities and clinical performance.

Dataset Information

A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET.

Publications

A 1-week extension of a ketogenic diet provides a further decrease in myocardial <sup>18</sup>F-FDG uptake and a high detectability of myocarditis with FDG-PET.

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