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Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection.

ABSTRACT: Hepatic steatosis (HS) is frequently observed in HIV-infected patients. It is not known whether HIV infection is an independent risk factor for HS development. We aimed to analyze whether HIV coinfection was associated with a higher frequency of HS in patients with chronic hepatitis C. This was a retrospective cross-sectional study. 574 subjects with chronic hepatitis C virus (HCV) infection were included, 246 (43%) of them coinfected with HIV. All of them underwent transient elastography with controlled attenuation parameter (CAP) measurement. HS was defined as CAP???248?dB/m. 147 individuals (45%) showed HS in the HCV-monoinfected group and 100 (40.7%) in the HIV/HCV-coinfected group (p?=?0.318). HS was associated with body mass index (BMI) [<25 Kg/m² vs. ?25 Kg/m², 67 (23.5%) vs. 171 (62.9%); p?=?0.001], with plasma HDL-cholesterol [<50?mg/dL vs. ?50?mg/dL, 122 (48.6%) vs. 95 (37.5%), p?=?0.012], with plasma triglycerides [<150?mg/dL vs. ?150?mg/dL, 168 (40.2%) vs. 65 (52.4%); p?=?0.016] and with plasma total cholesterol [<200?mg/dL vs. ?200?mg/dL, 181 (41%) vs. 53 (52.5%); p?=?0.035]. In the multivariate analysis, HS was associated with BMI [adjusted OR (AOR)?=?1.264 (1.194-1.339); p?=?0.001], age [AOR?=?1.029 (1.001-1.058); p?=?0.047] and HCV genotype 3 infection [AOR?=?1.901 (1.081-2.594); p?=?0.026]. HIV coinfection was not associated with HS [AOR?=?1.166 (0.719-1.892); p?=?0.534]. In conclusion, HIV coinfection is not related with an increased frequency of HS in HCV-infected patients.

SUBMITTER: Fernandez-Fuertes M

PROVIDER: S-EPMC7174281 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection.

Fernandez-Fuertes M M Macías J J Corma-Gómez A A Rincón P P Merchante N N Gómez-Mateos J J Pineda J A JA Real L M LM

Scientific reports 20200421 1

Hepatic steatosis (HS) is frequently observed in HIV-infected patients. It is not known whether HIV infection is an independent risk factor for HS development. We aimed to analyze whether HIV coinfection was associated with a higher frequency of HS in patients with chronic hepatitis C. This was a retrospective cross-sectional study. 574 subjects with chronic hepatitis C virus (HCV) infection were included, 246 (43%) of them coinfected with HIV. All of them underwent transient elastography with c ...[more]

PMID: 32317646

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Project description:Most chronically-infected hepatitis C virus (HCV) patients have increased levels of iron in the liver. Iron overload reduces sustained responses to antiviral therapy, leading to more rapid progression to liver cirrhosis and the development of hepatocellular carcinoma. However, it is still unclear how HIV-1 infection affects iron status in patients chronically infected with HCV. The present study recruited 227 patients from a village in central China. These patients were either monoinfected with HCV (n?=?129) or coinfected with HCV/HIV-1 (n?=?98). Healthy controls (n?=?84) were also recruited from the same village. Indicators of iron status, such as serum levels of iron, ferritin, and transferrin, total iron-binding capacity (TIBC), transferrin saturation (Tfs), and hepcidin, were analyzed and compared across the three groups. The results showed that serum levels of iron (p?=?0.001) and ferritin (p?=?0.009) and the Tfs (p?=?0.002) were significantly higher in HCV-monoinfected patients than in the healthy controls; however, there were no differences in iron levels and Tfs between HCV/HIV-1 coinfected patients and healthy controls. Additionally, although serum hepcidin levels in HCV-monoinfected and HCV/HIV-1-coinfected patients were lower (p<0.001) than those in health controls, the levels in coinfected patients were higher (p?=?0.025) than those in HCV-monoinfected patients. Serum iron and ferritin levels in HCV-monoinfected patients were positively correlated with serum ALT/AST. Serum transferrin levels were negatively correlated with ALT/AST levels. The levels of iron in the serum of coinfected patients with a CD4+T-cell count <500/µl were lower than those in patients with a CD4+T-cell count ?500/µl, whereas serum hepcidin levels showed the opposite trend. Taken together, these results suggest that coinfection with HIV-1 alleviates iron accumulation caused by chronic HCV infection. Our study indicated that determining the status of serum iron and other iron-associated parameters will be helpful to understand the complexity of alternations in iron distribution in HCV/HIV-1-coinfected patients.

Dataset Information

Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection.

Publications

Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection.

Similar Datasets

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