Ontology highlight
ABSTRACT:
SUBMITTER: Bonnemann V
PROVIDER: S-EPMC7174573 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Bönnemann Vivian V Claus Maren M Butzeck Barbara B Collette Daniela D Bröde Peter P Golka Klaus K Watzl Carsten C
EXCLI journal 20200325
Hereditary hemochromatosis (HH) is an autosomal-recessive disorder of the iron metabolism. Patients are typically affected by dysregulated iron levels, which can lead to iron accumulation within essential organs, such as liver, heart and pancreas. Furthermore, many HH patients are also afflicted by several immune defects and increased occurrence of autoimmune diseases that are linked to human homeostatic iron regulator protein (HFE) in the immune response. Here we examined immune cell phenotype ...[more]