Ontology highlight
ABSTRACT:
SUBMITTER: Atacho DAM
PROVIDER: S-EPMC7174873 | biostudies-literature | 2020 Mar/Apr
REPOSITORIES: biostudies-literature
Atacho Diahann A M DAM Reynisson Hallur H Petursdottir Anna Thora AT Eysteinsson Thor T Steingrimsson Eirikur E Petersen Petur Henry PH
eNeuro 20200301 2
Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor (<i>Mitf</i>) plays a central role in intrinsic plasticity of olfactory bulb (OB) projection neurons. Mitral and tufted (M/T) neurons from <i>Mitf</i> mutant mice are hyperexcitable, have a reduced A-type potassium current (I<sub>A</sub>) and exhibit reduced expression of <i>Kcnd3</i>, which encodes a potassium voltage ...[more]