Ontology highlight
ABSTRACT:
SUBMITTER: Mijit M
PROVIDER: S-EPMC7175209 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Mijit Mahmut M Caracciolo Valentina V Melillo Antonio A Amicarelli Fernanda F Giordano Antonio A
Biomolecules 20200308 3
The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle arrest that has a crucial role in aging, and it also represents a robust physiological antitumor response, which counteracts oncogenic insults. In addition, senescent cells can also negatively impact t ...[more]