Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice.
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ABSTRACT:
SUBMITTER: Freitas-Andrade M
PROVIDER: S-EPMC7175267 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice.
Freitas-Andrade Moises M Bechberger John J Wang Jasmine J Yeung Ken K C KKC Whitehead Shawn N SN Hansen Rie Shultz RS Naus Christian C CC
Biomolecules 20200226 3
Ischemic stroke is a complex and devastating event characterized by cell death resulting from a transient or permanent arterial occlusion. Astrocytic connexin43 (Cx43) gap junction (GJ) proteins have been reported to impact neuronal survival in ischemic conditions. Consequently, Cx43 could be a potential target for therapeutic approaches to stroke. We examined the effect of danegaptide (ZP1609), an antiarrhythmic dipeptide that specifically enhances GJ conductance, in two different rodent stroke ...[more]
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