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Targeting ?-synuclein for PD Therapeutics: A Pursuit on All Fronts.

ABSTRACT: Parkinson's Disease (PD) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy Bodies contain the aggregated ?-synuclein (?-syn) protein, which has been shown to be able to propagate from cell to cell and throughout different regions in the brain. Due to its central role in the pathology and the lack of a curative treatment for PD, an increasing number of studies have aimed at targeting this protein for therapeutics. Here, we reviewed and discussed the many different approaches that have been studied to inhibit ?-syn accumulation via direct and indirect targeting. These analyses have led to the generation of multiple clinical trials that are either completed or currently active. These clinical trials and the current preclinical studies must still face obstacles ahead, but give hope of finding a therapy for PD with time.

SUBMITTER: Teil M

PROVIDER: S-EPMC7175302 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.

Teil Margaux M Arotcarena Marie-Laure ML Faggiani Emilie E Laferriere Florent F Bezard Erwan E Dehay Benjamin B

Biomolecules 20200303 3

Parkinson's Disease (PD) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy Bodies contain the aggregated α-synuclein (α-syn) protein, which has been shown to be able to propagate from cell to cell and throughout different regions in the brain. Due to its central role in the pathology and the lack of a curative treatment for PD, an increasing number of studies have aimed at targeting this pro ...[more]

PMID: 32138193

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