Ontology highlight
ABSTRACT:
SUBMITTER: Futami M
PROVIDER: S-EPMC7176125 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Futami Muneyoshi M Suzuki Keisuke K Kato Satomi S Ohmae Saori S Tahara Yoshio Y Nojima Masanori M Imai Yoichi Y Mimura Takayuki T Watanabe Yoshihiro Y Tojo Arinobu A
PloS one 20200422 4
Cancer immunotherapy using chimeric antigen receptor-armed T (CAR T) cells have been shown to improve outcomes significantly in patients with hematological malignancies. However, cytokine release syndrome (CRS) remains a risk. CRS is characterized by the excessive activation of CAR T cells and macrophages. Signs and symptoms of CRS are usually resolved after steroid administration, but steroids abrogate the expansion and persistence of CAR T cell populations. Tocilizumab is a humanized monoclona ...[more]