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Mating Enhances Expression of Hormonal and Trophic Factors in the Midbrain of Female Rats.

ABSTRACT: Among female rats, mating enhances neurosteroid formation in the midbrain ventral tegmental area (VTA; independent of peripheral steroid-secreting glands, ovaries, and adrenals). The sources/targets for these actions are not well understood. In Experiment 1, proestrous rats engaged in a mating paradigm, or did not, and the midbrains had been assessed via the Affymetrix rat genome microarrays. In Experiment 2, the influence of gonadal and adrenal glands on the expression of these genes was assessed in rats that were proestrous, ovariectomized (OVX), or OVX and adrenalectomized (ADX). The microarrays revealed 53 target genes that were significantly up-regulated (>2.0-fold change) in response to mating. Mating significantly enhanced the midbrain mRNA expression of genes involved in hormonal and trophic actions: Gh1, S100g, and Klk1b3 in proestrous, but not OVX and/or ADX, rats; Fshb in all but OVX/ADX rats; and lutenizing hormone ? and thyroid-stimulating hormone (TSH) ? in all rats. Thus, mating enhances midbrain gene expression independent and dependent of peripheral glands.

SUBMITTER: Frye CA

PROVIDER: S-EPMC7176275 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Mating Enhances Expression of Hormonal and Trophic Factors in the Midbrain of Female Rats.

Frye Cheryl A CA Chittur Sridar V SV

Frontiers in behavioral neuroscience 20200415

Among female rats, mating enhances neurosteroid formation in the midbrain ventral tegmental area (VTA; independent of peripheral steroid-secreting glands, ovaries, and adrenals). The sources/targets for these actions are not well understood. In Experiment 1, proestrous rats engaged in a mating paradigm, or did not, and the midbrains had been assessed <i>via</i> the Affymetrix rat genome microarrays. In Experiment 2, the influence of gonadal and adrenal glands on the expression of these genes was ...[more]

PMID: 32351369

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Project description:Apart from hysterectomy, there is no consensus recommendation for reducing endometrial cancer risk for women with a mismatch repair gene mutation (Lynch syndrome).To investigate the association between hormonal factors and endometrial cancer risk in Lynch syndrome.A retrospective cohort study included 1128 women with a mismatch repair gene mutation identified from the Colon Cancer Family Registry. Data were analyzed with a weighted cohort approach. Participants were recruited between 1997 and 2012 from centers across the United States, Australia, Canada, and New Zealand.Age at menarche, first and last live birth, and menopause; number of live births; hormonal contraceptive use; and postmenopausal hormone use.Self-reported diagnosis of endometrial cancer.Endometrial cancer was diagnosed in 133 women (incidence rate per 100 person-years, 0.29; 95% CI, 0.24 to 0.34). Endometrial cancer was diagnosed in 11% (n?=?70) of women with age at menarche greater than or equal to 13 years compared with 12.6% (n?=?57) of women with age at menarche less than 13 years (incidence rate per 100 person-years, 0.27 vs 0.31; rate difference, -0.04 [95% CI, -0.15 to 0.05]; hazard ratio per year, 0.85 [95% CI, 0.73 to 0.99]; P?=?.04). Endometrial cancer was diagnosed in 10.8% (n?=?88) of parous women compared with 14.4% (n?=?40) of nulliparous women (incidence rate per 100 person-years, 0.25 vs 0.43; rate difference, -0.18 [95% CI, -0.32 to -0.04]; hazard ratio, 0.21 [95% CI, 0.10 to 0.42]; P?<?.001). Endometrial cancer was diagnosed in 8.7% (n?=?70) of women who used hormonal contraceptives greater than or equal to 1 year compared with 19.2% (n?=?57) of women who used contraceptives less than 1 year (incidence rate per 100 person-years, 0.22 vs 0.45; rate difference, -0.23 [95% CI, -0.36 to -0.11]; hazard ratio, 0.39 [95% CI, 0.23 to 0.64]; P?<?.001). There was no statistically significant association between endometrial cancer and age at first and last live birth, age at menopause, and postmenopausal hormone use.For women with a mismatch repair gene mutation, some endogenous and exogenous hormonal factors were associated with a lower risk of endometrial cancer. These directions and strengths of associations were similar to those for the general population. If replicated, these findings suggest that women with a mismatch repair gene mutation may be counseled like the general population in regard to hormonal influences on endometrial cancer risk.

Dataset Information

Mating Enhances Expression of Hormonal and Trophic Factors in the Midbrain of Female Rats.

Publications

Mating Enhances Expression of Hormonal and Trophic Factors in the Midbrain of Female Rats.

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