A powerful and versatile colocalization test.

ABSTRACT: Transcriptome-wide association studies (TWAS and PrediXcan) have been increasingly applied to detect associations between genetically predicted gene expressions and GWAS traits, which may suggest, however do not completely determine, causal genes for GWAS traits, due to the likely violation of their imposed strong assumptions for causal inference. Testing colocalization moves it closer to establishing causal relationships: if a GWAS trait and a gene's expression share the same associated SNP, it may suggest a regulatory (and thus putative causal) role of the SNP mediated through the gene on the GWAS trait. Accordingly, it is of interest to develop and apply various colocalization testing approaches. The existing approaches may each have some severe limitations. For instance, some methods t

SUBMITTER: Deng Y 

PROVIDER: S-EPMC7176287 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature