Reconfiguration of functional brain networks and metabolic cost converge during task performance.

ABSTRACT: The ability to solve cognitive tasks depends upon adaptive changes in the organization of whole-brain functional networks. However, the link between task-induced network reconfigurations and their underlying energy demands is poorly understood. We address this by multimodal network analyses integrating functional and molecular neuroimaging acquired concurrently during a complex cognitive task. Task engagement elicited a marked increase in the association between glucose consumption and functional brain network reorganization. This convergence between metabolic and neural processes was specific to feedforward connections linking the visual and dorsal attention networks, in accordance with task requirements of visuo-spatial reasoning. Further increases in cognitive load above initial task en

SUBMITTER: Hahn A 

PROVIDER: S-EPMC7176400 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature