FOXO1 deficiency impairs proteostasis in aged T cells.
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ABSTRACT:
SUBMITTER: Jin J
PROVIDER: S-EPMC7176426 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
FOXO1 deficiency impairs proteostasis in aged T cells.
Jin Jun J Li Xuanying X Hu Bin B Kim Chulwoo C Cao Wenqiang W Zhang Huimin H Weyand Cornelia M CM Goronzy Jorg J JJ
Science advances 20200422 17
T cell differentiation involves the dynamic regulation of FOXO1 expression, which rapidly declines after activation and is subsequently restored. Reexpression is impaired in naïve CD4<sup>+</sup> T cell responses from older individuals. Here, we show that FOXO1 promotes lysosome function through the induction of the key transcription factor for lysosomal proteins, TFEB. Subdued FOXO1 reexpression in activated CD4<sup>+</sup> T cells impairs lysosomal activity, causing an expansion of multivesicu ...[more]
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