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The Genetic Association of IFN-?s with Human Inflammatory Disorders Remains a Conundrum.

ABSTRACT: Type III Interferons (IFNs) or lambda IFNs (IFN-?s or IFNLs) although are primarily antiviral cytokines, may have roles to play in shaping immune responses, including those during inflammation. Genetic variants within the IFNL locus have been shown to be associated with various inflammatory conditions in humans ranging from metabolic to autoimmune and allergic diseases. The mechanism behind these genetic associations is not clear. Appropriate data analysis methods and functional evidence should be complimentarily used to identify the causal variants and mechanisms.

SUBMITTER: Chinnaswamy S

PROVIDER: S-EPMC7176482 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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The Genetic Association of IFN-λs with Human Inflammatory Disorders Remains a Conundrum.

Chinnaswamy Sreedhar S Kowalski Marek L ML

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20190604 10

Type III Interferons (IFNs) or lambda IFNs (IFN-λs or IFNLs) although are primarily antiviral cytokines, may have roles to play in shaping immune responses, including those during inflammation. Genetic variants within the <i>IFNL</i> locus have been shown to be associated with various inflammatory conditions in humans ranging from metabolic to autoimmune and allergic diseases. The mechanism behind these genetic associations is not clear. Appropriate data analysis methods and functional evidence ...[more]

PMID: 31161954

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