The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.

ABSTRACT: CCRL2 is a nonsignaling seven-transmembrane domain receptor. CCRL2 binds chemerin, a protein that promotes chemotaxis of leukocytes, including macrophages and natural killer (NK) cells. In addition, CCRL2 controls the inflammatory response in different pathologic settings, such as hypersensitivity, inflammatory arthritis, and experimental autoimmune encephalitis. Here, we investigated the role of CCRL2 in the regulation of lung cancer-related inflammation. The genetic deletion of Ccrl2 promoted tumor progression in urethane-induced and in Kras ^G12D/+/p53 ^LoxP lung tumor mouse models. Similarly, a Kras-mutant lung tumor displayed enhanced growth in Ccrl2-deficient mice. This phenotype was associated with a reduced inflammatory infiltr

SUBMITTER: Del Prete A 

PROVIDER: S-EPMC7176487 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature