Sex differences in leukocyte profile in ST-elevation myocardial infarction patients.

ABSTRACT:

Background

Whether sex differences exist in the inflammatory response after ST-elevation myocardial infarction (STEMI) remains to be elucidated. We studied leukocyte profiles and their prognostic value in men and women presenting with STEMI.

Methods

From a total of 552 consecutive STEMI patients, blood samples were collected at hospital admission. Linear regression was used to assess the relationship between leukocyte profiles and enzymatic infarct size. Cox regression was used to assess the association between leukocyte profiles and one-year mortality.

Results

Women presented with higher lymphocyte counts (2.3·10⁹?cells/L (IQR 1.6-3.1) vs. 1.8·10⁹?cells/L (IQR 1.4-2.5), p?=?3.00???10^-4) and percentages (21.1% (IQR 14.4-28.1) vs. 17.1% (IQR 12.3-24.3), p?=?0.004). Lymphocyte to monocyte ratio (LMR) was also higher in women (3.25 (IQR 2.56-4.5) vs. 2.68 (IQR 2.08-3.59), p?=?7.28???10^-7). Higher LMR was associated with lower peak CK-MB (??=?-0.27 (95% CI: -0.50, -0.03), p?=?0.026), lower peak troponin T (??=?-0.45 (95% CI: -0.77, -0.13), p?=?0.006) and lower one-year mortality risk (HR 0.35 (95% CI: 0.13, 0.96), p?=?0.042).

Conclusion

At admission for STEMI, women present with higher lymphocyte count and LMR. Higher LMR is associated with smaller infarct size and decreased one-year mortality risk and could be used as a biomarker to predict outcome.

SUBMITTER: van Blokland IV 

PROVIDER: S-EPMC7176674 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature