Deficiency of CD44 prevents thoracic aortic dissection in a murine model.
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ABSTRACT:
SUBMITTER: Hatipoglu OF
PROVIDER: S-EPMC7176701 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Deficiency of CD44 prevents thoracic aortic dissection in a murine model.
Hatipoglu Omer F OF Miyoshi Toru T Yonezawa Tomoko T Kondo Megumi M Amioka Naofumi N Yoshida Masashi M Akagi Satoshi S Nakamura Kazufumi K Hirohata Satoshi S Ito Hiroshi H
Scientific reports 20200422 1
Thoracic aortic dissection (TAD) is a life-threatening vascular disease. We showed that CD44, a widely distributed cell surface adhesion molecule, has an important role in inflammation. In this study, we examined the role of CD44 in the development of TAD. TAD was induced by the continuous infusion of β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, and angiotensin II (AngII) for 7 days in wild type (WT) mice and CD44 deficient (CD44<sup>-/-</sup>) mice. The incidence of TAD in CD44<sup>- ...[more]
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