Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort.
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ABSTRACT:
SUBMITTER: Osborne AJ
PROVIDER: S-EPMC7176736 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort.
Osborne Amy J AJ Pearson John F JF Noble Alexandra J AJ Gemmell Neil J NJ Horwood L John LJ Boden Joseph M JM Benton Miles C MC Macartney-Coxson Donia P DP Kennedy Martin A MA
Translational psychiatry 20200422 1
Cannabis use is of increasing public health interest globally. Here we examined the effect of heavy cannabis use, with and without tobacco, on genome-wide DNA methylation in a longitudinal birth cohort (Christchurch Health and Development Study, CHDS). A total of 48 heavy cannabis users were selected from the CHDS cohort, on the basis of their adult exposure to cannabis and tobacco, and DNA methylation assessed from whole blood samples, collected at approximately age 28. Methylation in heavy can ...[more]
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