Ontology highlight
ABSTRACT:
SUBMITTER: Stoner MW
PROVIDER: S-EPMC7177173 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Stoner Michael W MW McTiernan Charles F CF Scott Iain I Manning Janet R JR
Physiological reports 20200401 8
The global burden of heart failure following myocardial ischemia-reperfusion (IR) injury is a growing problem. One pathway that is key to understanding the progression of myocardial infarction and IR injury is the endoplasmic reticulum (ER) stress pathway, which contributes to apoptosis signaling and tissue death. The role of calreticulin in the progression of ER stress remains controversial. We hypothesized that calreticulin induction drives proapoptotic signaling in response to ER stress. We f ...[more]