Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics.
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ABSTRACT:
SUBMITTER: Cassidy FC
PROVIDER: S-EPMC7177361 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics.
Cassidy Féaron C FC Shortiss Ciara C Murphy Colin G CG Kearns Stephen R SR Curtin William W De Buitléir Ciara C O'Brien Timothy T Coleman Cynthia M CM
International journal of molecular sciences 20200402 7
Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in numerous disease settings involving impaired regeneration because of the crucial role they play in tissue maintenance and repair. Considering the number of comorbidities associated with type 2 diabetes mellitus (T2DM), the hypothesis that MSCs mediate these comorbidities via a reduction in their native maintenance and repair activities is an intriguing line of inquiry. Here, it is demonstrated that the number of ...[more]
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