Ontology highlight
ABSTRACT:
SUBMITTER: Dengler F
PROVIDER: S-EPMC7177550 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200331 7
AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor, mediating the adaptation to low energy levels by deactivating anabolic processes and activating catabolic processes in order to restore the cellular ATP supply when the cellular AMP/ATP ratio is increased. Besides this well-known role, it has also been shown to exert protective effects under hypoxia. While an insufficient supply with oxygen might easily deplete cellular energy levels, i.e., ATP concentration, manif ...[more]