Ontology highlight
ABSTRACT:
SUBMITTER: Mason ER
PROVIDER: S-EPMC7177867 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Mason Emily R ER Cummins Theodore R TR
International journal of molecular sciences 20200401 7
Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by epilepsy mutations in the Nav1.2 channel, but conventional antiepileptic drugs inhibit normal transient currents through these channels, along with aberrant resurgent and persistent currents that are enhanced by Nav1.2 epilepsy mutations. Pharmacotherapies that specifically target aberrant resurgent and/or persistent currents would likely have fewer unwanted side effect ...[more]