Ontology highlight
ABSTRACT:
SUBMITTER: Uras IZ
PROVIDER: S-EPMC7178035 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Uras Iris Z IZ Sexl Veronika V Kollmann Karoline K
International journal of molecular sciences 20200405 7
Acute myeloid leukemia (AML) is a complex disease with an aggressive clinical course and high mortality rate. The standard of care for patients has only changed minimally over the past 40 years. However, potentially useful agents have moved from bench to bedside with the potential to revolutionize therapeutic strategies. As such, cell-cycle inhibitors have been discussed as alternative treatment options for AML. In this review, we focus on cyclin-dependent kinase 6 (CDK6) emerging as a key molec ...[more]