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Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers.


ABSTRACT: Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific biological information and have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Here, we survey the evolutionary origin, general characteristics, and biological significance of extracellular vesicles as mediators of intercellular signaling, discuss the various subtypes of extracellular vesicles thus far described and the principal methodological approaches to their study, and review the role of extracellular vesicles in tumorigenesis, immunity, non-synaptic neural communication, vascular-neural communication through the blood-brain barrier, renal pathophysiology, and embryo-fetal/maternal communication through the placenta.

SUBMITTER: Simeone P 

PROVIDER: S-EPMC7178048 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers.

Simeone Pasquale P   Bologna Giuseppina G   Lanuti Paola P   Pierdomenico Laura L   Guagnano Maria Teresa MT   Pieragostino Damiana D   Del Boccio Piero P   Vergara Daniele D   Marchisio Marco M   Miscia Sebastiano S   Mariani-Costantini Renato R  

International journal of molecular sciences 20200404 7


Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific biological information and have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Here, we survey the evolutionary origin, general characteristics, and biological significance of extracellular vesicles as mediators of intercellular signaling, discuss the various subtypes of extracellular vesicles thus far described and the pri  ...[more]

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