Ontology highlight
ABSTRACT:
SUBMITTER: Bradley T
PROVIDER: S-EPMC7178423 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bradley Thomas T Moxon Simon S
Bioinformatics (Oxford, England) 20200401 8
<h4>Motivation</h4>MicroRNA (miRNA) target prediction algorithms do not generally consider biological context and therefore generic target prediction based on seed binding can lead to a high level of false-positive predictions. Here, we present FilTar, a method that incorporates RNA-Seq data to make miRNA target prediction specific to a given cell type or tissue of interest.<h4>Results</h4>We demonstrate that FilTar can be used to: (i) provide sample specific 3'-UTR reannotation; extending or tr ...[more]