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Elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis of patients with primary gastrointestinal stromal tumor.

ABSTRACT: BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are considered to reflect the systemic inflammatory response and clinical prognosis. However, the independent prognostic values of the NLR and PLR for patients with gastrointestinal stromal tumor (GIST) remain debatable. This study aims to evaluate the prognostic value of preoperative NLR and PLR in GIST patients. METHODS:We retrospectively reviewed all GIST patients diagnosed and surgically treated at Union Hospital between 2005 and 2018. The preoperative NLR and PLR were calculated to evaluate recurrence-free survival (RFS) and overall survival (OS) by Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were performed to estimate the independent prognostic values. RESULTS:The median follow-up time was 49?months (interquartile range, 22-74?months). The preoperative PLR was significantly increased in the GIST patients with intermediate and high tumor risks. Increases in the NLR (?2.34) and PLR (?185.04) were associated with shorter RFS and OS (P?

SUBMITTER: Chang WL 

PROVIDER: S-EPMC7178594 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis of patients with primary gastrointestinal stromal tumor.

Chang Wei-Long WL   Yang Wen-Chang WC   Zeng Xiang-Yu XY   Li Cheng-Guo CG   Xiong Zhen Z   Wang Tao T   Zhang Rui-Zhi RZ   Tao Kai-Xiong KX   Zhang Peng P  

BMC gastroenterology 20200422 1

<h4>Background</h4>The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are considered to reflect the systemic inflammatory response and clinical prognosis. However, the independent prognostic values of the NLR and PLR for patients with gastrointestinal stromal tumor (GIST) remain debatable. This study aims to evaluate the prognostic value of preoperative NLR and PLR in GIST patients.<h4>Methods</h4>We retrospectively reviewed all GIST patients diagnosed and surgically  ...[more]