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ABSTRACT: Background
Cardiac dysfunction is increasingly recognized in patients with liver cirrhosis. Nevertheless, the presence or absence of structural alterations such as diffuse myocardial fibrosis remains unclear. We aimed to investigate myocardial structural changes in cirrhosis, and explore left ventricular (LV) structural and functional changes induced by liver transplantation.Methods
This study included 33 cirrhosis patients listed for transplantation and 20 healthy controls. Patients underwent speckle-tracking echocardiography and cardiovascular magnetic resonance (CMR) with extracellular volume fraction (ECV) quantification at baseline (n?=?33) and 1?year after transplantation (n?=?19).Results
CMR-based LV ejection fraction (CMRLV-EF) and echocardiographic LV global longitudinal strain (LV-GLS) demonstrated hyper-contractile LV in cirrhosis patients (CMRLV-EF: 67.8?±?6.9% in cirrhosis vs 63.4?±?6.4% in healthy controls, P?=?0.027; echocardiographic GLS: -?24.2?±?2.7% in cirrhosis vs -?18.6?±?2.2% in healthy controls, P??0.1). Only one of the cirrhosis patients showed late gadolinium enhancement. However, cirrhosis patients showed a higher ECV (31.6?±?5.1% vs 25.4?±?1.9%, P?ConclusionsMyocardial extracellular volume expansion with augmented resting LV systolic function was characteristic of cirrhotic cardiomyopathy, which normalizes 1-year post-transplantation. Thus, myocardial extracellular expansion represents a structural component of myocardial changes in cirrhosis.
SUBMITTER: Kim HM
PROVIDER: S-EPMC7178724 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kim Hyue Mee HM Kim Hyung-Kwan HK Lee Jeong-Hoon JH Lee Yun Bin YB Park Eun-Ah EA Park Jun-Bean JB Lee Seung-Pyo SP Kim Yoon Jun YJ Kim Yong-Jin YJ Yoon Jung-Hwan JH Sohn Dae-Won DW
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20200423 1
<h4>Background</h4>Cardiac dysfunction is increasingly recognized in patients with liver cirrhosis. Nevertheless, the presence or absence of structural alterations such as diffuse myocardial fibrosis remains unclear. We aimed to investigate myocardial structural changes in cirrhosis, and explore left ventricular (LV) structural and functional changes induced by liver transplantation.<h4>Methods</h4>This study included 33 cirrhosis patients listed for transplantation and 20 healthy controls. Pati ...[more]