Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome.

ABSTRACT: BACKGROUND:Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology. METHODS:We conducted a nested case-control study within the Syncope Study of Unselected Population in Malmö (SYSTEMA) cohort including 396 patients (age range, 15-50?years) with either POTS (n?=?113) or normal hemodynamic response during passive head-up-tilt test (n?=?283). We used a targeted approach to explore changes in cardiovascular proteomics associated with POTS through a sequential two-stage process including supervised principal component analysis and univariate ANOVA with Bonferroni correction. RESULTS:POTS patients were younger (26 vs. 31?years; p?

SUBMITTER: Medic Spahic J 

PROVIDER: S-EPMC7178975 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature