Impact of baseline symptoms and health status on COPD exacerbations in the FLAME study.
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ABSTRACT:
SUBMITTER: Mackay AJ
PROVIDER: S-EPMC7179005 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Impact of baseline symptoms and health status on COPD exacerbations in the FLAME study.
Mackay Alexander J AJ Kostikas Konstantinos K Roche Nicolas N Frent Stefan-Marian SM Olsson Petter P Pfister Pascal P Gupta Pritam P Patalano Francesco F Banerji Donald D Wedzicha Jadwiga A JA
Respiratory research 20200422 1
<h4>Background</h4>COPD is a heterogeneous disease and patients may respond differently to therapies depending on baseline symptom burden.<h4>Methods</h4>This post-hoc analysis from the 52-week FLAME study investigated the impact of baseline symptom burden in terms of health status, dyspnoea, bronchitis status, eosinophil levels and smoking status on the subsequent risk of moderate or severe exacerbations. Health status was measured by St. George's Respiratory Questionnaire (SGRQ) score (higher ...[more]
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Project description:A review of the most relevant evidence based therapeutic options currently available for the management of exacerbations of COPD.
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