Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease.

ABSTRACT:

Introduction

Non-motor symptoms such as cognitive and gastrointestinal (GI) symptoms are common in Parkinson's disease (PD). In PD, GI-symptoms often present prior to motor symptoms. It is hypothesized that GI-symptoms reflect disruptions of the microbiome-gut-brain axis, which leads to altered immune functioning, chronic neuroinflammation, and subsequent neurodegeneration. Initial evidence links gut-dysbiosis to PD pathology and motor symptom severity. The present study examines the longitudinal relationship between severity of GI-symptoms and cognitive impairment in newly diagnosed PD patients.

Methods

A secondary data analysis of the Parkinson's Progression Markers Initiative (PPMI) included 423 newly diagnosed PD patients who were followed for up to 5 years. Participants

SUBMITTER: Jones JD 

PROVIDER: S-EPMC7179075 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature