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A Multispecies Cluster of VIM-1 Carbapenemase-Producing Enterobacterales Linked by a Novel, Highly Conjugative, and Broad-Host-Range IncA Plasmid Forebodes the Reemergence of VIM-1.


ABSTRACT: In this study, we investigated VIM-1-producing Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Citrobacter freundii, and Enterobacter cloacae strains, isolated in 2019 during a period of active surveillance of carbapenem-resistant Enterobacterales in a large university hospital in Italy. VIM-1-producing strains colonized the gut of patients, with up to three different VIM-1-positive bacterial species isolated from a single rectal swab, but also caused bloodstream infection in one colonized patient. In the multispecies cluster, bla VIM-1 was identified in a 5-gene cassette class 1 integron, associated with several genetic determinants, including the bla SHV-12, qnrS1, and mph(A) genes, located on a highly conjugative and broad-host-range IncA plasmid. The characteristics and origin of this IncA plasmid were studied.

SUBMITTER: Arcari G 

PROVIDER: S-EPMC7179263 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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A Multispecies Cluster of VIM-1 Carbapenemase-Producing <i>Enterobacterales</i> Linked by a Novel, Highly Conjugative, and Broad-Host-Range IncA Plasmid Forebodes the Reemergence of VIM-1.

Arcari Gabriele G   Di Lella Federica Maria FM   Bibbolino Giulia G   Mengoni Fabio F   Beccaccioli Marzia M   Antonelli Guido G   Faino Luigi L   Carattoli Alessandra A  

Antimicrobial agents and chemotherapy 20200324 4


In this study, we investigated VIM-1-producing <i>Escherichia coli</i>, <i>Klebsiella oxytoca</i>, <i>Klebsiella pneumoniae</i>, <i>Citrobacter freundii</i>, and <i>Enterobacter cloacae</i> strains, isolated in 2019 during a period of active surveillance of carbapenem-resistant <i>Enterobacterales</i> in a large university hospital in Italy. VIM-1-producing strains colonized the gut of patients, with up to three different VIM-1-positive bacterial species isolated from a single rectal swab, but a  ...[more]

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