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Hydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms.

ABSTRACT: The antibiofilm activity of a hydrogen peroxide-generating electrochemical scaffold (e-scaffold) was determined against mono- and trispecies biofilms of methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and Candida albicans Significant time-dependent decreases were found in the overall CFU of biofilms of all three monospecies and the trispecies forms. Confocal laser scanning microscopy showed dramatic reductions in fluorescence intensities of biofilm matrix protein and polysaccharide components of e-scaffold-treated biofilms. The described e-scaffold has potential as a novel antibiotic-free strategy for treating wound biofilms.

SUBMITTER: Raval YS

PROVIDER: S-EPMC7179276 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Hydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms.

Raval Yash S YS Mohamed Abdelrhman A Song James J Greenwood-Quaintance Kerryl E KE Beyenal Haluk H Patel Robin R

Antimicrobial agents and chemotherapy 20200324 4

The antibiofilm activity of a hydrogen peroxide-generating electrochemical scaffold (e-scaffold) was determined against mono- and trispecies biofilms of methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and Candida albicans Significant time-dependent decreases were found in the overall CFU of biofilms of all three monospecies and the trispecies forms. Confocal laser scanning microscopy showed dramatic reductions in fluorescence intensit ...[more]

PMID: 31964793

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| S-EPMC2761203 | biostudies-literature

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| S-EPMC3057177 | biostudies-literature

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