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Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada.

ABSTRACT: Three new inositol angelate compounds (1-3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC₅₀ value at 8.4 and 13.2 ?M. In addition, compounds 4 and 5 also showed remarkable growth inhibitory activity to Artemia salina larvae.

SUBMITTER: Yang SX

PROVIDER: S-EPMC7179408 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada.

Yang Sheng-Xiang SX Song Cheng-Gang CG Kuang Yi Y Liu Bing B Zhang Yan-Xin YX Zhang Ming-Zhe MZ Zhang Chun-Ying CY Ding Gang G Qin Jian-Chun JC

Molecules (Basel, Switzerland) 20200309 5

Three new inositol angelate compounds (1-3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC50 value at 8.4 and 13.2 μM. In addition, compounds ...[more]

PMID: 32182779

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