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Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates.

ABSTRACT: As important cancer therapeutic agents, macrocyclic peptides have recently drawn great attention, mainly because they are synthetically accessible and have lower toxicity towards normal cells. In the present work, we synthesized newly macrocyclic pyridoheptapeptide derivatives. The synthesized derivatives were characterized using standard chemical and spectroscopic analytical techniques, and their anticancer activities against human breast and hepatocellular cancer cells were investigated. Results showed that compounds 1a and 1b were the most effective against hepatocellular (HepG2) and breast (MCF-7) cancer cell lines, respectively.

SUBMITTER: Abo-Ghalia MH

PROVIDER: S-EPMC7179445 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates.

Abo-Ghalia Mohamed H MH Moustafa Gaber O GO Amr Abd El-Galil E AEE Naglah Ahmed M AM Elsayed Elsayed A EA Bakheit Ahmed H AH

Molecules (Basel, Switzerland) 20200310 5

As important cancer therapeutic agents, macrocyclic peptides have recently drawn great attention, mainly because they are synthetically accessible and have lower toxicity towards normal cells. In the present work, we synthesized newly macrocyclic pyridoheptapeptide derivatives. The synthesized derivatives were characterized using standard chemical and spectroscopic analytical techniques, and their anticancer activities against human breast and hepatocellular cancer cells were investigated. Resul ...[more]

PMID: 32164321

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