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Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model.


ABSTRACT: Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against Enterococcus faecalis, Enterococcus faecium (resistant to vancomycin and ampicillin), and Staphylococcus aureus As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while DAP for 5 days was significantly effective against these bacteria. Step-down therapy (DAP for 3 days followed by TZD for 2 days) was as effective as DAP for 5 days and was comparable to 3 days of DAP plus ceftriaxone against all bacteria and to 3 days of DAP plus gentamicin against E. faecalis OG1RF.

SUBMITTER: Singh KV 

PROVIDER: S-EPMC7179605 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model.

Singh Kavindra V KV   Arias Cesar A CA   Murray Barbara E BE  

Antimicrobial agents and chemotherapy 20200421 5


Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against <i>Enterococcus faecalis</i>, <i>Enterococcus faecium</i> (resistant to vancomycin and ampicillin), and <i>Staphylococcus aureus</i> As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while DAP for 5 days was significantly effective against these bacteria. Step-down therapy (DAP for 3 days followed by TZD for 2 days) was as effective as DAP for 5 days and was compara  ...[more]

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