Ontology highlight
ABSTRACT:
SUBMITTER: Souza E
PROVIDER: S-EPMC7179609 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Souza Ernane E Crass Ryan L RL Felton Jeremy J Hanaya Kengo K Pai Manjunath P MP
Antimicrobial agents and chemotherapy 20200421 5
In patients with renal impairment (<i>n</i> = 22 of 39), the median serum concentrations of linezolid, PNU-142300, and PNU-142586 were 1.6-, 3.3-, 2.8-fold higher, respectively, than in patients without renal impairment. Metabolite concentrations in paired samples were poorly correlated with linezolid concentrations (<i>r</i><sup>2</sup> = 0.26 for PNU-142300 and 0.06 for PNU-142586). Linezolid and its metabolites share potential toxicophores that deserve characterization to mitigate higher myel ...[more]