Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis.
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ABSTRACT:
SUBMITTER: Walsh KF
PROVIDER: S-EPMC7179618 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis.
Walsh K F KF McAulay K K Lee M H MH Vilbrun S C SC Mathurin L L Jean Francois D D Zimmerman M M Kaya F F Zhang N N Saito K K Ocheretina O O Savic R R Dartois V V Johnson W D WD Pape J W JW Nathan C C Fitzgerald D W DW
Antimicrobial agents and chemotherapy 20200421 5
This study was conducted in treatment-naive adults with drug-susceptible pulmonary tuberculosis in Port-au-Prince, Haiti, to assess the safety, bactericidal activity, and pharmacokinetics of nitazoxanide (NTZ). This was a prospective phase II clinical trial in 30 adults with pulmonary tuberculosis. Twenty participants received 1 g of NTZ orally twice daily for 14 days. A control group of 10 participants received standard therapy over 14 days. The primary outcome was the change in time to culture ...[more]
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