Unorthodox Parenteral ?-Lactam and ?-Lactamase Inhibitor Combinations: Flouting Antimicrobial Stewardship and Compromising Patient Care.
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ABSTRACT:
SUBMITTER: Palwe S
PROVIDER: S-EPMC7179625 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Unorthodox Parenteral β-Lactam and β-Lactamase Inhibitor Combinations: Flouting Antimicrobial Stewardship and Compromising Patient Care.
Palwe Snehal S Veeraraghavan Balaji B Periasamy Hariharan H Khobragade Kshama K Kharat Arun S AS
Antimicrobial agents and chemotherapy 20200421 5
In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy ass ...[more]
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