Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms.
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ABSTRACT:
SUBMITTER: Frapwell CJ
PROVIDER: S-EPMC7179629 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms.
Frapwell C J CJ Skipp P J PJ Howlin R P RP Angus E M EM Hu Y Y Coates A R M ARM Allan R N RN Webb J S JS
Antimicrobial agents and chemotherapy 20200421 5
<i>Staphylococcus aureus</i> biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of <i>S. aureus</i> UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing <i>Staphylococcus</i> spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as ...[more]
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