Ontology highlight
ABSTRACT:
SUBMITTER: Rice CA
PROVIDER: S-EPMC7179646 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20200421 5
<i>Balamuthia mandrillaris</i> is an under-reported, pathogenic free-living amoeba that causes <i>Balamuthia</i> amoebic encephalitis (BAE) and cutaneous skin infections. Although cutaneous infections are not typically lethal, BAE with or without cutaneous involvement is usually fatal. This is due to the lack of drugs that are both efficacious and can cross the blood-brain barrier. We aimed to discover new leads for drug discovery by screening the open-source Medicines for Malaria Venture (MMV) ...[more]