Ontology highlight
ABSTRACT:
SUBMITTER: Sokolov V
PROVIDER: S-EPMC7180004 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20200306 4
The aim of this research was to differentiate dapagliflozin, empagliflozin, and canagliflozin based on their capacity to inhibit sodium-glucose cotransporter (SGLT) 1 and 2 in patients with type 2 diabetes using a previously developed quantitative systems pharmacology model of renal glucose filtration, reabsorption, and excretion. The analysis was based on pooled, mean study-level data on 24-hour urinary glucose excretion, average daily plasma glucose, and estimated glomerular filtration rate co ...[more]