Ontology highlight
ABSTRACT:
SUBMITTER: Pucino V
PROVIDER: S-EPMC7180190 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pucino Valentina V Certo Michelangelo M Varricchi Gilda G Marone Giancarlo G Ursini Francesco F Rossi Francesca Wanda FW De Paulis Amato A Mauro Claudio C Raza Karim K Buckley Christopher Dominic CD
Frontiers in physiology 20200417
Several studies have highlighted the interplay between metabolism, immunity and inflammation. Both tissue resident and infiltrating immune cells play a major role in the inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipo-cytokines and metabolic intermediates. These functions are metabolically demanding and require the most efficient use of bioenergetic pathways. The synovial membrane is the primary site of inflammation in RA and exhibits distinctive histolog ...[more]