Ontology highlight
ABSTRACT:
SUBMITTER: Da Pieve C
PROVIDER: S-EPMC7180749 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Da Pieve Chiara C Makarem Ata A Turnock Stephen S Maczynska Justyna J Smith Graham G Kramer-Marek Gabriela G
Molecules (Basel, Switzerland) 20200329 7
Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide-thiol reaction (Michael addition). When maleimide-functionalized chelators are used and the resulting bioconjugates are subsequently radiolabeled, instability has been observed both during radiosynthesis and post-injection in vivo, reducing radiochemical yield and negatively impacting performance. Recently, a phenyloxadiazolyl methylsulfone derivative (PODS) was proposed as an alterna ...[more]