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Cellular Internalization of Beta-Carotene Loaded Polyelectrolyte Multilayer Capsules by Raman Mapping.


ABSTRACT: Raman mapping is becoming a very useful tool in investigating cells and cellular components, as well as bioactive molecules intracellularly. In this study, we have encapsulated beta-carotene using a layer-by-layer technique, as a way to enhance its stability and bioavailability. Further, we have used Raman mapping to characterize the as-obtained capsules and monitor their uptake by the human retinal epithelial D407 cells. We were able to successfully map the beta-carotene distribution inside the capsules, to localize the capsules intracellularly, and distinguish between capsules and other cellular components.

SUBMITTER: Leopold LF 

PROVIDER: S-EPMC7181117 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Cellular Internalization of Beta-Carotene Loaded Polyelectrolyte Multilayer Capsules by Raman Mapping.

Leopold Loredana F LF   Marișca Oana O   Oprea Ioana I   Rugină Dumitrița D   Suciu Maria M   Nistor Mădălina M   Tofană Maria M   Leopold Nicolae N   Coman Cristina C  

Molecules (Basel, Switzerland) 20200325 7


Raman mapping is becoming a very useful tool in investigating cells and cellular components, as well as bioactive molecules intracellularly. In this study, we have encapsulated beta-carotene using a layer-by-layer technique, as a way to enhance its stability and bioavailability. Further, we have used Raman mapping to characterize the as-obtained capsules and monitor their uptake by the human retinal epithelial D407 cells. We were able to successfully map the beta-carotene distribution inside the  ...[more]

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