Ontology highlight
ABSTRACT:
SUBMITTER: Nizzardo M
PROVIDER: S-EPMC7181443 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nizzardo M M Taiana M M Rizzo F F Aguila Benitez J J Nijssen J J Allodi I I Melzi V V Bresolin N N Comi G P GP Hedlund E E Corti S S
Acta neuropathologica 20200217 5
In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs). The mechanisms responsible for this selective degeneration are largely unknown, but the molecular signatures of resistant and vulnerable motor neurons are distinct and offer clues to neuronal resilience and susceptibility. Here, we demonstrate that healthy OMNs preferentially express Synaptot ...[more]