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Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population.


ABSTRACT: This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10-13 provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait.

SUBMITTER: Haidar M 

PROVIDER: S-EPMC7181444 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population.

Haidar Mahdi M   Alsaleh Hussain H   Haddrill Penelope R PR  

International journal of legal medicine 20191114 3


This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10<sup>-13<  ...[more]

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