Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC7181644 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Yu Yan Y Zhao Dan D Li Kongfei K Cai Yubo Y Xu Penglin P Li Rui R Li Juan J Chen Xiaolong X Chen Ping P Cui Guangying G
Cell death & disease 20200424 4
The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was positively correlated with large tumor size, tumor multiplicity, late tumor-node-metastasis (TNM) stage and poor prognosis. Additional, gain-of-function and loss-of-function experiment ...[more]