Ontology highlight
ABSTRACT:
SUBMITTER: Corona RI
PROVIDER: S-EPMC7181647 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200424 1
The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landscapes of primary OCs using H3K27ac ChIP-seq and RNA-seq, and then integrate these with whole genome sequencing data from 232 OCs. We identify 25 frequently mutated regulatory elements, including an enhancer at 6p22.1 which associates with differential expressio ...[more]