Ontology highlight
ABSTRACT:
SUBMITTER: Ganz J
PROVIDER: S-EPMC7181660 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Ganz Javier J Shacham Talya T Kramer Maria M Shenkman Marina M Eiger Hagit H Weinberg Nitai N Iancovici Ori O Roy Somnath S Simhaev Luba L Da'adoosh Benny B Engel Hamutal H Perets Nisim N Barhum Yael Y Portnoy Moshe M Offen Daniel D Lederkremer Gerardo Z GZ
Scientific reports 20200423 1
One of the pathways of the unfolded protein response, initiated by PKR-like endoplasmic reticulum kinase (PERK), is key to neuronal homeostasis in neurodegenerative diseases. PERK pathway activation is usually accomplished by inhibiting eIF2α-P dephosphorylation, after its phosphorylation by PERK. Less tried is an approach involving direct PERK activation without compromising long-term recovery of eIF2α function by dephosphorylation. Here we show major improvement in cellular (STHdh<sup>Q111/111 ...[more]