Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC7181720 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Journal of molecular cell biology 20200401 3
NF-κB signaling regulates diverse processes such as cell death, inflammation, immunity, and cancer. The activity of NF-κB is controlled by methionine 1-linked linear polyubiquitin, which is assembled by the linear ubiquitin chain assembly complex (LUBAC) and the ubiquitin-conjugating enzyme UBE2L3. Recent studies found that the deubiquitinase OTULIN breaks the linear ubiquitin chain, thus inhibiting NF-κB signaling. Despite the essential role of OTULIN in NF-κB signaling has been established, th ...[more]